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Endocrine Abstracts

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ea0084op-07-36 | Oral Session 7: Thyroid Cancer Basic | ETA2022

Loss of tumor cell MHC class ii expression as driver of relapse to dabrafenib and trametinib in mouse BRAF-mutant anaplastic thyroid cancer

Tiedje Vera , Qin Tianyue , Im Soo-Yeon , P Krishnamoorthy Gnana , A. Knauf Jeffrey , A. Fagin James

Objectives: BRAFV600E- anaplastic thyroid cancers (ATCs) show remarkable responses to dabrafenib and trametinib (dab/tram) an effect that may be in part immune-mediated. Murine BRAFV600E-ATCs regress upon BRAF inhibition. We find that recurrences are frequent and associated with loss of Mhc class II (MhcII) expression. Our goal was to investigate the mechanisms of loss of antigen presentation by tumor cells and whether this contributes to disease recurren...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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